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In these BPH studies, Proscar did not appear to alter the rate of prostate cancer detection, and the overall incidence of prostate cancer was not significantly different in patients treated with Proscar or placebo. Combination therapy significantly reduced the risk of symptom score progression compared to the effect of Proscar alone (p<0. 001) in patients treated with Proscar, doxazosin, or the combination, respectively, compared to patients treated with placebo (see Figure 5). Analysis of PSA data from over 3000 patients in PLESS confirmed that in typical patients treated with Proscar for six months or more, PSA values should be doubled for comparison with normal ranges in untreated men. The ratio of free to total PSA remains constant even under the influence of Proscar.
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