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Chloroquine also is taken up into the acidic food vacuoles of the parasite in the erythrocyte. In suppressive treatment, chloroquine inhibits the erythrocytic stage of development of plasmodia {01} {02} {06} {29}. In addition, resistance to both chloroquine and the sulfadoxine and pyrimethamine combination is widespread in Thailand, Myanmar, Cambodia, and the Amazon basin area of South America; resistance also has been reported sporadically in sub-Saharan Africa {35}. If chloroquine hydrochloride injection is given intravenously in pediatric patients, it should be diluted and administered very slowly. However, risk-benefit must be considered since chloroquine, given in therapeutic doses, has been shown to cause central nervous system (CNS) damage, including ototoxicity (auditory and vestibular); congenital deafness; retinal hemorrhages; and abnormal retinal pigmentation {01} {02} {06}.

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