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Clinical studies have shown that with co-administration of Casodex, mean midazolam (a CYP 3A4 substrate) levels may be increased 1. 71) higher in the Casodex group and in the smaller trial (N=140), the risk of death was 36% (HR 0. Hence, caution should be exercised when Casodex is co-administered with CYP 3A4 substrates. These are three multicenter, randomized, double-blind, parallel group trials comparing Casodex 150 mg daily monotherapy (adjuvant to previous therapy or under watchful waiting) with placebo, for death or time to disease progression, in a population of 8113 patients with localized or locally advanced prostate cancer. See CLINICAL PHARMACOLOGY-Clinical Studies- Safety Data from Clinical Studies using Casodex 150 mg section for additional important safety information regarding Casodex 150 mg. You may not be able to take Casodex, or you may need a dose adjustment or special tests during treatment.
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